Revealing high-resolution views of the depth and breadth of the proteome

Fuzzy and incomplete views of the proteome make it hard to identify the best drug targets. Persistent clinical failures and incredible expenses result. Our platform is designed to reveal the most promising drug targets by enabling researchers to comprehensively explore the proteins at work in disease and identify the patterns of modification that drive their dysfunction.

The most successful biomarkers measure proteins as real time markers of health and disease. However, current technologies have difficulty identifying what proteins and patterns of protein modification are most saliently associated with biological functions. By employing single-molecule analysis to measure the full breadth of the proteome and the precise modifications on active proteins, our platform is designed to identify the most informative indicators of health.

Proteins and their diverse single-molecule proteoforms drive biology, but proteomics tools for measuring them are inaccessible to most labs. To help researchers understand how biology works at a mechanistic level, we plan to democratize proteomics with integrated, accessible workflows, straightforward data, and a suite of cloud-based analysis tools that will enable researchers in any field to establish foundational biological insights.

Proteins are modified in myriad ways as they adopt their active forms. Researchers have coined the term “proteoforms” to define the specific versions of single-molecule proteins functioning in biological systems. We must quantify proteoforms to understand how proteins participate in diverse biological pathways, but no accessible technologies exist to measure them. With our single-molecule protein analysis capabilities, we are developing targeted proteoform analysis methods that quantify the mix of proteoforms driving biology.